Home Medizin Zusammenhang zwischen Darmmikrobiom und vorzeitiger Alterung bei chronischen HIV-Patienten enthüllt

Zusammenhang zwischen Darmmikrobiom und vorzeitiger Alterung bei chronischen HIV-Patienten enthüllt

von NFI Redaktion


The extraordinary professor at The Wistar Institute, Mohamed Abdel-Mohsen, Ph.D., and his team have recently established a link between viral damage in the gut and premature biological aging. Their findings suggest a connection between gut permeability, and early systemic and intestinal tissue aging in people with chronic HIV infection. These groundbreaking discoveries are detailed in their newly published article titled „Distinct Intestinal Microbial Signatures Linked to Accelerated Systemic and Intestinal Biological Aging,“ released in the journal Microbiome.

Rapid biological aging, a condition known as accelerated biological aging, makes individuals more susceptible to serious health concerns typically seen in older adults, including cancer, heart disease, brain diseases, severe infections, and reduced vaccine efficacy. Dr. Abdel-Mohsen’s work aims to investigate the factors driving this rapid aging and explore ways to slow down biological aging and improve overall health.

The main suspect in this aging puzzle is the gut microbiome and its potential to leak into the bloodstream. Abdel-Mohsen’s lab is investigating how gut leaks impact the immune system and can lead to chronic inflammation, which accelerates the aging process.

To investigate, Dr. Abdel-Mohsen and his team analyzed samples from people with chronic HIV infection, known for accelerating biological age, making them an excellent model for examining the mechanisms of accelerated biological aging in chronically ill individuals.

The study focused on colon, ileum, stool, and blood samples from people with chronic HIV infection and well-matched controls. Their analysis revealed a significant association between disrupted gut microbiomes, increased gut permeability (Leaky Gut), and faster biological aging.

In particular, they observed a link between accelerated biological aging and the microbiomes of both the colon and ileum, but not the fecal microbiome. This highlights the importance of sampling gut tissue to understand the connection between microbiome and aging accurately.

The biological age can be measured using advanced methods like telomere length analysis and „epigenetic clocks“ such as the Hannum and Horvath clocks, which estimate age based on DNA methylation patterns. Abdel-Mohsen’s team’s application of multiple advanced methods to measure biological age in blood and gut tissue samples is the first analysis of its kind in people with HIV, and their investigation into the connection between the gut microbiome and biological age in this population is a pioneering study of aging effects in chronic HIV infections on the microbiome.

The team’s work highlights specific bacteria and their by-products as potential accelerators of aging. These findings open up new possibilities for developing strategies to combat these bacteria and their by-products, potentially prolonging good health in the lives of people with chronic conditions like chronic infections.

Further investigations are required to fully understand the underlying causes and potential impacts of our findings. There is also an urgent need to develop strategies to prevent gut dysbiosis and gut leaks and to determine how these strategies could affect a person’s biological age. Our work is just the beginning of an exciting journey towards improving health and longevity.

Dr. Mohamed Abdel-Mohsen, Ph.D., Extraordinary Professor, The Wistar Institute

Source:

Journal Reference:

Singh, S., et al. (2024) Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging. Microbiome. doi.org/10.1186/s40168-024-01758-4.

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