Home Medizin Untersuchungen zeigen Zusammenhang zwischen Umweltschadstoffen und Gebärmutterkrebs

Untersuchungen zeigen Zusammenhang zwischen Umweltschadstoffen und Gebärmutterkrebs

von NFI Redaktion

Research conducted by UGR, IDIBELL, the Catalan Institute of Oncology, and the Biohealth Research Institute in Granada (ibs.GRANADA), published in the journal Environmental Health Perspectives, has revealed a connection between environmental pollutants and endometrial cancer. Scientists and doctors from the Bellvitge University Hospital and the Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP) participated in this collaborative study.

Endometrial cancer is a type of tumor that develops in the uterine lining. It accounts for over 5,000 new cases of cancer in Spain every year and has significant implications for women’s health. Furthermore, the incidence of this type of cancer is increasing, partly due to the aging population. Since it is a hormone-dependent cancer, estrogens may play a role in its development and progression.

The study examined the relationship between endometrial cancer and exposure to mixtures of environmental pollutants that can disrupt hormone function. These chemicals, also known as endocrine disruptors, act as xenoestrogens and are present in many industrial products, including pesticides, herbicides, as well as in cosmetics and other everyday consumer goods.

Using advanced chemical analysis techniques and biological tests, researchers identified the overall hormonal burden in the blood of over 300 women with and without endometrial cancer. „Employing these biological tests helps us understand the negative effects of chemical mixtures,“ explains Marieta Fernández, UGR professor and researcher at the Biohealth Research Institute in Granada (ibs.GRANADA) and CIBERESP.

The results indicate a link between exposure to endocrine disruptors and an increased risk of developing endometrial cancer. „Interestingly, we observed the effect at moderate doses of xenoestrogens, but not at high doses, similar to endogenous hormones,“ adds Laura Costas, researcher at IDIBELL and the Catalan Institute of Oncology.

Given that this is a hormone-dependent cancer, this link is likely related to the nature of the tumor itself. Therefore, we also want to investigate whether the presence of xenoestrogens leads to a worse pathological development in women already suffering from the disease.“ says Costas, who is also a researcher at CIBERESP.

The research sheds light on the negative effects of endocrine disruptors on human health and has significant implications for public health. It also emphasizes the need to consider the combined effects of chemical mixtures when assessing environmental risks.


Journal Reference:

Costas, L., et al. (2024) Overall Effective Xenoestrogen Exposure in Serum Samples and Risk of Endometrial Cancer in the Spanish Screenwide Case-Control Study. Environmental Health Perspectives. doi.org/10.1289/EHP13202.

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