Home Medizin Studie zeigt unerwartete Rolle des BCG-Impfstoffs bei der Bekämpfung der Grippe

Studie zeigt unerwartete Rolle des BCG-Impfstoffs bei der Bekämpfung der Grippe

von NFI Redaktion

As the flu season in Canada collides with a record number of Strep A cases and ongoing concerns about COVID-19, a new study sheds light on our understanding of respiratory immune responses. Scientists at the Research Institute of the McGill University Health Center (RI-MUHC) have uncovered a surprising facet of a centuries-old vaccine against tuberculosis, Bacillus Calmette Guérin (BCG). The study, published in the journal Nature Immunology, discovered a previously unknown mechanism that extends the protective shield of the vaccine to combat the influenza A virus – the most widely spread flu strain.

The immune interactions involved here can „train“ the lungs, which are often exposed to environmental pathogens. Deciphering the protective immune pathways involved in the lungs will revolutionize our conceptual and clinical approaches in developing vaccines against infections, including emerging respiratory viruses.“

Maziar Divangahi, lead author, lung immunologist, Senior Scientist at RI-MUHC and Professor of Medicine at McGill University

The discovery paves the way for future studies to assess whether BCG could be used for preventing other emerging viruses. In particular, research on the vaccine’s protection against COVID-19 has shown promising results.


Journal Reference:

Tran, KA, et al. (2024). BCG immunization induces CX3CR1hi effector memory T cells to provide cross-protection via IFN-γ mediated trained immunity. Nature Immunology. doi.org/10.1038/s41590-023-01739-z.

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