Home Medizin Studie zeigt geringere kardiovaskuläre Risiken bei Patienten mit Hyperthyreose, die mit einer Operation oder radioaktivem Jod behandelt werden

Studie zeigt geringere kardiovaskuläre Risiken bei Patienten mit Hyperthyreose, die mit einer Operation oder radioaktivem Jod behandelt werden

von NFI Redaktion


Hyperthyroidism, or an overactive thyroid, occurs when your thyroid gland produces more thyroid hormones than your body needs. Excess thyroid hormones due to an overactive thyroid increase cardiovascular risk. While hyperthyroidism can be treated with thyroid medications, radioactive iodine ablation, or surgery, comparing the long-term benefits and risks of the three treatment modalities poses a challenge for informed decision-making and likely contributes to variations in treatment.

In a new study from the Chobanian & Avedisian School of Medicine at Boston University, researchers found that patients with hyperthyroidism who were treated with surgery had a 47% lower risk of mortality and a 24% lower risk of severe adverse cardiovascular events compared to patients treated with medications. They also found that patients treated with radioactive iodine had a 55% lower likelihood of severe cardiovascular events compared to those treated with medications.

„While there are three main treatment options for this condition, the choice of therapy must be individualized – there is no one-size-fits-all solution. Our study suggests that considering a person’s cardiovascular risk may be important in decisions regarding hyperthyroidism treatment.“

– Elizabeth Pearce, MD, MSc, Co-corresponding Author, Professor of Medicine, Boston University Chobanian & Avedisian School of Medicine

The researchers used data from 114,062 patients in Taiwan’s National Health Insurance Research Database diagnosed with hyperthyroidism between 2011 and 2020. They compared the frequency of severe cardiovascular events (acute myocardial infarction, stroke, heart failure, and cardiovascular death) and all-cause mortality among patients treated with each of the three types of hyperthyroidism treatments.

According to the researchers, thyroid surgery or treatment with radioactive iodine may be better treatment options for patients with hyperthyroidism who also have a high risk of cardiovascular disease than long-term use of thyroid medications. „The improved outcomes observed with surgical interventions or radioactive iodine in our study may be related to a faster and more complete resolution of hyperthyroidism than what was achieved with medications. However, future prospective studies will be necessary to better understand these risks,“ added Pearce, an endocrinologist at Boston Medical Center.

These results appear online in JAMA Network Open.

Source:

Boston University School of Medicine

Journal Reference:

Peng, CC-H., et al. (2024). MACE and hyperthyroidism treated with medications, radioactive iodine, or thyroid removal. JAMA Network Open. doi.org/10.1001/jamanetworkopen.2024.0904

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