It is now well documented that the outbreak of the coronavirus has triggered a global health crisis. In this study, researchers wanted to know if and to what extent impairment of the blood-brain barrier contributes to the development of neurological problems during the progression of COVID-19. The blood-brain barrier is a filter mechanism of capillaries that transport blood to the brain and spinal cord tissues while blocking the passage of certain toxic substances. The results show that „COVID-19-associated blood plasma inflammation factors do not have a direct impact on the paracellular route of the blood-brain barrier,“ the researchers wrote. Furthermore, the results suggest that „pathological remodeling of the blood-brain barrier during COVID-19, if at all, may occur through indirect or as yet unknown mechanisms.“ The study will be published in the journal Function.
„Several pieces of evidence suggest that cerebral vascular dysfunction is a common feature of COVID-19,“ wrote the research team. „Therefore, it is important to understand the complex relationships between blood cytokine/chemokine profiles, blood-brain barrier integrity, and the severity of the neurological manifestations of COVID-19.“
American Physiological Society (APS)
Pociūtė, A., et al. (2024). Plasma from COVID-19 patients does not alter the electrical resistance of the human endothelial blood-brain barrier In vitro. Function. doi.org/10.1093/function/zqae002.