Home Medizin Studie untersucht den Einfluss von mütterlichem HS auf die Ergebnisse bei Nachkommen

Studie untersucht den Einfluss von mütterlichem HS auf die Ergebnisse bei Nachkommen

von NFI Redaktion

The maternal Hidradenitis suppurativa (HS) is associated with an increased risk of adverse birth outcomes and childhood morbidities, including respiratory, metabolic, central nervous system, and other diseases.

These are key findings of a longitudinal cohort study presented during a poster session at the annual meeting of the American Academy of Dermatology.

„HS is associated with morbidity in women of childbearing age and adverse pregnancy outcomes.“ However, „its impact on offspring outcomes remains unclear,“ wrote lead author Kaiyang Li, a third-year medical student at McGill University, Quebec, Canada, and co-authors in their summary.

To investigate the association between maternal HS and offspring outcomes at birth and with a follow-up period of up to 16 years, the researchers drew on a longitudinal cohort of 1,275,593 children born in Quebec between April 1, 2006 and March 31, 2022. They matched the children with their mothers and tracked the children using identification numbers to record morbidities leading to hospitalizations before their 16th birthday. The exposure of interest was HS, and the primary outcome measure was childhood hospitalizations due to respiratory, cardiovascular, metabolic, and other morbidities before the age of 16.

Next, they estimated Hazard Ratios (HR) and 95% CIs for the association of maternal HS with childhood morbidity in adjusted Cox Proportional Hazards regression models. „As prenatal exposure to hyperandrogenism may influence boys and girls differently, we conducted subgroup analyses stratified by the children’s gender,“ they wrote.

The study population included 1,283 children whose mothers had HS and 1,274,310 unexposed children. As for infant outcomes, maternal HS was associated with an increased risk of preterm birth (relative risk [RR], 1.29; 95% CI, 1.08–1.55), neonatal death (RR, 2.07; 95% CI, 1.03–14.13), birth defects (RR, 1.29; 95% CI, 1.07–1.56), congenital heart defects (RR, 1.57; 95% CI, 1.02–2.44), and orofacial defects (RR 4.29; 95% CI, 1.85–9.97).

As for long-term outcomes in children, maternal HS compared to those whose mothers did not have HS, was associated with an increased risk of childhood hospitalizations (HR: 1.31; 95% CI: 1.19–1.44) and hospitalizations related to respiratory infections (HR 1.21; 95% CI, 1.05–1.40), metabolic hospitalizations (HR, 2.64; 95% CI, 1.67–4.20), gastrointestinal hospitalizations (HR, 1.34; 95% CI, 1.03–1.74), and developmental hospitalizations (HR, 1.92; 95% CI: 1.43–2.58).

The researchers disclosed no financial disclosures. The abstract was selected as the runner-up in the AAD Poster Competition.

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