Home Medizin Studie deckt unerwartetes Maß an Komplexität auf, das in Neutrophilen verborgen ist

Studie deckt unerwartetes Maß an Komplexität auf, das in Neutrophilen verborgen ist

von NFI Redaktion

Published in Cell on March 5, a study by Prof. Zhang Xiaoming from the Shanghai Institute of Immunity and Infection (SIII) of the Chinese Academy of Sciences and Profs. Gao Qiang, Fan Jia, and Yang Li from Fudan University has uncovered a previously unexpected level of complexity hidden within neutrophils, which were previously thought to be a relatively uniform population of short-lived immune cells.

Using state-of-the-art single-cell RNA sequencing technology, the researchers analyzed individual neutrophils across 17 different notable cancer types from 143 patients. They demonstrated that neutrophils can adopt at least ten highly specialized and distinct functional states associated with inflammation, blood vessel formation, and most excitingly, antigen presentation to activate effective cancer-killing T cells.

We were surprised to find such complex diversity and varied roles within neutrophils, which had been overlooked for so long as a simple population. Particularly remarkable is their newly discovered ability to act as antigen-presenting cells and mature T cells against cancer. Furthermore, the abundance of antigen-presenting neutrophils is associated with improved patient prognosis across many tumor types revealed in this study.

Prof. Zhang Xiaoming, Shanghai Institute of Immunity and Infection (SIII) of the Chinese Academy of Sciences

Through extensive analysis, the researchers found that this antigen-presenting state can be activated by metabolic signals from the amino acid leucine and resulting epigenetic changes. „We have discovered a way to awaken an untapped army already living in our immune system. Strategically activating these neutrophil states or modulating their behavior through metabolic or dietary measures presents a completely new paradigm for enhancing cancer immunotherapy,“ said Prof. Zhang.

The researchers subsequently validated the therapeutic potential of these findings using in vivo models. They found that the delivery of antigen-presenting neutrophils or simply modulating the leucine diet dramatically enhanced the anti-tumor immune response in mice and significantly improved the outcomes of PD-1 checkpoint immunotherapy in a variety of cancer types.

Related Posts

Adblock Detected

Please support us by disabling your AdBlocker extension from your browsers for our website.