Home Medizin Proteine ​​des Immunsystems können manipuliert werden, um bei der Bekämpfung von Darmkrebs zu helfen

Proteine ​​des Immunsystems können manipuliert werden, um bei der Bekämpfung von Darmkrebs zu helfen

von NFI Redaktion

According to a new study by the Australian National University (ANU), a protein in the immune system can be manipulated to help fight against colorectal cancer.

Colorectal cancer claims over 100 lives in Australia every week, but around 90% of cases can be successfully treated if detected early.

Lead author Dr. Abhimanu Pandey of the ANU suggests that the protein known as Ku70 can be activated or „switched on“ like a light switch through the combination of new and existing medications.

When in its activated state, the protein acts as a surveillance system, detecting signs of damaged DNA in our cells.

DNA is the genetic code of life. Damaged DNA is a sign of danger that can transform healthy cells into cancerous cells.

Our research shows that Ku70 can „cool down“ cancer cells and remove damaged DNA. The protein prevents the cancer cells from becoming more aggressive and spreading throughout the body by essentially deactivating them and keeping them in a dormant state,“ said Dr. Abhimanu Pandey, ANU.

Colorectal cancer is the fourth most diagnosed cancer in Australia. It is estimated that one in 20 individuals aged 85 will be diagnosed with colorectal cancer.

As part of the National Bowel Cancer Screening Program, Australians aged 50 to 74 receive a free colorectal cancer test every two years, an effective measure for promoting early detection and treatment.

While the risk of developing colorectal cancer is higher in individuals over 50 years old, the disease is being diagnosed in increasingly younger Australians. One out of every nine new cases of colorectal cancer now occurs in Australians under the age of 50.

Professor Si Ming Man, also from ANU, suggested that future methods for colorectal cancer prevention could involve assessing the levels of Ku70 in precancerous polyps, abnormal tissue growths in the colon, before healthy cells become cancerous.

„Our research shows that Ku70 is a good immune biomarker, meaning it helps us predict who will fare better or worse after a colorectal cancer diagnosis,“ Professor Man stated.

Before World Cancer Day on February 4th, ANU researchers are calling for people of all ages to be made aware of the signs and symptoms of colorectal cancer.

„We know that early detection and treatment are crucial not only for overcoming colorectal cancer but potentially for other types of cancer as well,“ Professor Man said. „We hope that the cancer research conducted at ANU on this important day contributes to raising awareness for the prevention, detection, and treatment of cancer.“

The research is published in Science Advances. Learn more about how ANU researchers are making significant strides in cancer research at ANU Reporter.

Source:

Australian National University

Journal reference:

Pandey, A., et al. (2024). Ku70 recognizes cytosolic DNA and organizes a tumor suppressive signalosome. Science Advances. doi.org/10.1126/sciadv.adh3409.

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