Ischemic cholecystitis is a form of gallbladder inflammation that occurs without the presence of gallstones or any other form of external compression. It is caused by poor blood supply to the gallbladder tissue.
This new research is important as it helps better understand the cause of ischemic cholecystitis and develop more effective treatments for this condition.
A research team at the University of California, San Francisco conducted a study to investigate the cause of ischemic cholecystitis. They found that the gallbladder is particularly vulnerable to ischemia, as it is supplied by an end artery that, if blocked, leaves no other artery to supply blood to the gallbladder.
The researchers also found that ischemic cholecystitis occurs more frequently in critically ill patients. This is because critically ill patients often experience hypovolemia, which is a decreased blood volume, leading to poor blood supply to the gallbladder, resulting in inflammation.
These findings have important implications for the diagnosis and treatment of ischemic cholecystitis. As the diagnosis is often challenging, ischemic cholecystitis may be misdiagnosed as another condition such as sepsis or pancreatitis, leading to treatment delays and poorer outcomes for patients.
The researchers also found that ischemic cholecystitis is more likely to recur than obstructive cholecystitis, meaning patients with ischemic cholecystitis are more likely to require gallbladder removal surgery.
The treatment for ischemic cholecystitis is the surgical removal of the gallbladder, the only way to prevent the condition from recurring.
Ischemic cholecystitis is a rare but serious condition that occurs more frequently in critically ill patients. It is crucial for doctors to be aware of this condition to promptly diagnose and treat it.
First Hospital of Jilin University
Favela, JG, et al. (2023). Etiology, Diagnosis and Management of Ischemic Cholecystitis: Current Perspectives. eGastroenterology. doi.org/10.1136/egastro-2023-100004.