Home Medizin Neu entdeckter Adhäsions-GPCR-Mayonnaise kontrolliert die Mitteldarmentwicklung bei Drosophila

Neu entdeckter Adhäsions-GPCR-Mayonnaise kontrolliert die Mitteldarmentwicklung bei Drosophila

von NFI Redaktion

Adhesion-GPCRs belong to the large family of G protein-coupled receptors (GPCRs). In humans, there are approximately 700 variants responsible for sensory perception, hormone cycles, cardiovascular control, and more. GPCRs translate stimuli from outside the cell into an intracellular biochemical signal.

The use of the fruit fly as a model organism allows researchers in this field to gain a deep understanding of human diseases, as these animals are genetically very similar to humans. Scientists estimate that around 75% of genes involved in human diseases are also present in fruit flies.

The research team at the Rudolf-Schönheimer Institute of Biochemistry at the Medical Faculty has discovered three new Adhesion-GPCR genes in the genome of the fruit fly Drosophila. One of them is evolutionarily ancient and has been named Mayonnaise. In the current publication, the Leipzig scientists demonstrate the functions of this Adhesion-GPCR in the living model of the fruit fly. „We found that Mayonnaise influences the development of the midgut in Drosophila by promoting the growth of enterocytes, the epithelial cells of the intestinal mucosa,“ says Dr. Beatriz Blanco-Redondo, corresponding author of the study.

The Leipzig scientists also show in their publication that the loss of Mayonnaise in the intestine accelerates the heart rate of the animals and leads to dangerous arrhythmias. The results suggest that the functions of the intestine and heart are interconnected through the role of Mayonnaise in enterocyte proliferation. These regulate and control secondary ion uptake, systemic potassium levels, and heart rate.

The researchers at Leipzig University studied animals in which the Mayonnaise gene was turned off. They found that these „knockout animals“ had elongated intestines. A similar genetic pattern was observed in mice when another Adhesion-GPCR was overexpressed in intestinal cells, leading to megacolon. The study shows that Adhesion-GPCRs are also involved in the development of the gastrointestinal tract in other species, and these phenomena may be relevant to humans as well.

„We are only at the beginning of this research project. The main goal is to identify the signaling pathway in which the Adhesion-GPCR Mayonnaise participates and to understand how it controls intestinal development.“

Tobias Langenhan, Professor of General Biochemistry at the Rudolf Schönheimer Institute and corresponding author of the study

Source:

Journal Reference:

Contreras, FV, et al. (2024). The Adhesion G-protein Coupled Receptor Mayo/CG11318 controls midgut development in Drosophila. Cell Reports. doi.org/10.1016/j.celrep.2023.113640.

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