Home Medizin Mikronadeln bieten eine vielversprechende Lösung für die Behandlung diabetischer Wunden

Mikronadeln bieten eine vielversprechende Lösung für die Behandlung diabetischer Wunden

von NFI Redaktion

Projections indicate that the global population of patients with diabetic wounds will increase to 9.1 to 26.1 million by 2030. Diabetic wounds significantly impact the quality of life of patients, both physically and mentally, and also pose a significant economic burden on healthcare systems.

Current treatment methods for diabetic wounds include surgical debridement, negative pressure wound therapy, vascularized flaps, and various types of local dressings. Among the most commonly used dressings are gauze, metal ion dressings, hydrogel dressings, and platelet-rich plasma dressings. However, conventional dressings have limited drug absorption capacity and permeability, and are unable to effectively transport active drugs to the deep wound bed.

In recent years, microneedles have emerged as a research focus in wound management due to their advantages of high drug loading/delivery capability, minimal invasiveness, convenience, and strong adhesion. These properties significantly reduce patient discomfort and improve compliance. Microneedles enhance the efficiency and permeability of transdermal drug delivery by penetrating the skin barrier, incorporating drugs, proteins, nanoparticles, and other therapeutic agents, and effectively transporting them to the wound bed.

Currently, there is a lack of comprehensive articles on the application of microneedles of different structures and materials in diabetic wounds. This also hinders the development of microneedle dressings for diabetic wounds.

To address this, a review published in the KeAi Journal titled Chinese Journal of Plastic and Reconstructive Surgery, summarizes the materials of microneedles, techniques, structure, design, release mechanism, classification of delivered substances, and their effects on various stages of wound healing.

The structural composition and material selection of microneedles influence their effectiveness in the treatment of diabetic wounds. Microneedles can promote wound healing in diabetics through various mechanisms, such as antibacterial, anti-inflammatory, antioxidant, hypoglycemic, and angiogenic effects in different phases of the healing process.“


Youbai Chen, corresponding author of the study, Professor of Plastic and Reconstructive Surgery at the First Medical Center of the Chinese PLA General Hospital, Beijing

„In conclusion, microneedles are promising drug delivery systems for the treatment of diabetic wounds,“ adds lead author Chun Liang. „We hope that our summary is insightful and educational for further research on microneedle dressings.“

Source:

Journal Reference:

Liang, C., et al. (2023). Revolutionizing diabetic wound healing: The power of microneedles. Chinese Journal of Plastic and Reconstructive Surgery. doi.org/10.1016/j.cjprs.2023.12.004.

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