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Laut Studie sind Frauen stärker gefährdet als Männer

von NFI Redaktion

According to a new study, depression has an impact on heart health, with women being at a particularly elevated risk for cardiovascular diseases compared to men.

Published in the JACC Journal, the study found that an earlier diagnosis of depression increased the risk of heart disease by 39 percent in men and 64 percent in women. The researchers hope that their findings will provide insight into the need to adjust strategies for the prevention and treatment of cardiovascular diseases (CVD) based on gender-specific factors.

„Identifying gender-specific factors in the negative effects of depression on cardiovascular outcomes can help in developing targeted prevention and treatment strategies that address the specific cardiovascular risks faced by patients with depression. A better understanding will enable healthcare providers to optimize care for both men and women with depression, leading to better cardiovascular outcomes for these populations,“ said Hidehiro Kaneko, a corresponding author of the study.

Previous studies have shown the correlation between depression and an increased risk of cardiovascular events such as heart attacks, angina, strokes, and death. While it has been noted that women with depression have a higher relative risk of cardiovascular issues compared to men, there is insufficient evidence of the impact due to gender differences, and the underlying mechanisms of this phenomenon are not fully understood.

To examine the relationship between depression and subsequent cardiovascular events, researchers conducted an observational cohort study with 4,125,720 participants from a Japanese insurance claims database. The participants had an average age of 44 years, with approximately 57 percent being men.

The study identified individuals with depression as those clinically diagnosed before their first health examination. The examination also gathered information on the participant’s body mass index (BMI), blood pressure, and fasting laboratory values. The primary endpoint consisted of a composite endpoint including heart attacks, chest pain, strokes, heart failure, and atrial fibrillation.

„Researchers analyzed the statistical significance of differences in clinical characteristics between participants with and without depression. The results suggest that the risk ratio of depression for cardiovascular diseases was 1.39 in men and 1.64 in women compared to participants without depression,“ the press release stated.

According to the researchers, women may face a higher risk of cardiovascular diseases when suffering from depression due to several factors. Women tend to have more severe and persistent symptoms of depression compared to men, especially during times of significant hormonal changes such as pregnancy or menopause.

Factors such as the higher vulnerability of women to traditional risk factors like high blood pressure, diabetes, and obesity, as well as differences in access to healthcare and treatment between genders and gender-specific biological factors, may contribute to the increased risk associated with depression.

„Our study found that the influence of gender differences on the connection between depression and cardiovascular outcomes was consistent. Healthcare professionals must recognize the important role of depression in the development of cardiovascular diseases and emphasize the significance of a comprehensive, patient-centered approach to their prevention,“ Kaneko said.

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