Home Medizin Kein Zusammenhang zwischen gewohnheitsmäßigem Koffeinkonsum und Migräne

Kein Zusammenhang zwischen gewohnheitsmäßigem Koffeinkonsum und Migräne

von NFI Redaktion


According to a new study, habitual caffeine consumption is not associated with the frequency, duration, or intensity of episodic migraine attacks. The researchers suggested that caffeine restrictions for migraine patients may not be necessary.


  • A secondary analysis of a prospective cohort study on sleep in adults with episodic migraine (with or without aura) included a group of 97 individuals (average age 31 years; 82% white) with an average of 5.0 ± 3.6 headache days per month at baseline.
  • Participants provided sociodemographic information, medical history, habitual caffeine beverage consumption, alcohol consumption, as well as lifestyle and psychosocial factors and completed the Center for Epidemiological Studies Depression Scale, Perceived Stress Scale, and Pittsburgh Sleep Quality Index.
  • In addition, they kept electronic diaries twice daily for the following six weeks, reporting headache activity and intake of headache medication.


  • Overall, 67% of participants reported consuming one to two servings of caffeinated beverages per day, 12% reported consuming three to four servings per day, and 21% reported no habitual caffeine consumption.
  • After adjusting for age, gender, oral contraceptives, and other confounding factors, the mean headache frequency was similar in the groups (7.1 days without caffeine, 7.4 days with one to two servings, and 5.9 days with three to four servings).
  • Likewise, the adjusted mean headache duration did not differ between the amounts of caffeinated beverage intake (8.6 hours for no caffeine, 8.5 hours for one to two servings, and 8.8 hours for three to four servings).
  • The adjusted mean headache intensity also did not differ between the groups.


„Our findings do not support a recommendation for individuals with episodic migraine to avoid habitual consumption of caffeinated beverages,“ the authors wrote. However, they noted that habitual caffeine intake may affect systems involved in pain modulation through adenosine signaling. „Therefore, it is possible that habitual caffeine consumption in migraine patients may not significantly alter adenosine signaling, but significant changes above or below usual consumption may serve as triggers or contribute to lowering the threshold for an attack,“ they added.


Suzanne M. Bertisch, MD, MPH, Assistant Professor of Medicine, Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, was the lead and corresponding author of the study. It was published online on February 6, 2024, in Headache.


The portion size was not standardized, and there was no information about the type of caffeinated beverage consumed or other sources of caffeine. Additionally, the population consisted of relatively healthy participants with episodic migraine and generally low habitual caffeine beverage consumption, limiting the statistical power to establish an association between migraine frequency, duration, and intensity with higher caffeine consumption.


The study was funded by the National Institute of Neurological Disorders and Stroke, the American Sleep Medicine Foundation, and the Harvard Catalyst/Harvard Clinical and Translational Science Center. Bertisch has conducted consulting activities for Idorsia and ResMed. The disclosures of the other authors are listed in the original paper.

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