Home Medizin Innovative plasmaaktivierte Hydrogel-Verbände revolutionieren die Versorgung chronischer Wunden

Innovative plasmaaktivierte Hydrogel-Verbände revolutionieren die Versorgung chronischer Wunden

von NFI Redaktion

A team of international scientists has developed an effective treatment for chronic wounds using ionized gas to activate wound dressings instead of antibiotics.

The treatment involves plasma activation of hydrogel dressings, commonly used in wound care, with a unique blend of various chemical oxidizing agents that are effective in decontamination and supporting the healing of chronic wounds.

Researchers from the University of Sheffield and the University of South Australia, leading the study, believe that the new method represents a significant advancement in combating antibiotic-resistant pathogens and has the potential to change the treatment of diabetic foot ulcers and internal wounds.

Professor Rob Short, Chemistry Professor at the University of Sheffield and co-author of the study, stated: „Globally, more than 540 million people live with diabetes, with 30% developing a foot ulcer in their lifetime.“ He emphasized the urgent need for innovation in wound management and treatment to address the escalating challenge.

The costs associated with treating chronic wounds like diabetic foot ulcers already exceed $17 billion per year.

The benefits of ionized cold plasma gas have been demonstrated in clinical studies, showing its ability to control infections and stimulate healing. This is attributed to the potent chemical cocktail of oxidation agents, reactive oxygen and nitrogen species (RONS), generated when mixing and activating oxygen and nitrogen molecules in the surrounding air.

Dr. Endre Szili from the University of South Australia, leading the study, published in the journal Advanced Functional Materials, remarked on the drawbacks of traditional wound treatments using antibiotics and silver dressings, signaling the need for alternative approaches.

The international team of scientists showed that plasma-activated hydrogel dressings loaded with RONS enhance the effectiveness of the gel and can kill common bacteria that infect wounds.

Despite focusing on diabetic foot ulcers, the technology is applicable to all chronic wounds and internal infections.

“Despite recent promising results with plasma-activated hydrogel therapy (PAHT), we faced the challenge of loading hydrogels with sufficient RONS concentrations required for clinical use. We overcame this hurdle by employing a novel electrochemical method that intensifies hydrogel activation.”

Dr. Endre Szili, University of South Australia

The researchers emphasize that the PAHT technology has the potential to not only kill common bacteria but also stimulate the body’s immune response against infections, addressing the silent pandemic of chronic wound infections that could escalate into a global health crisis.

Next steps include clinical trials to optimize the electrochemical technology for treating human patients.


Journal References:

Sumyea Sabrin, et al. (2024). Electrochemically Enhanced Antimicrobial Effect of Plasma-Activated Poly(vinyl alcohol) Hydrogel Dressings. Advanced Functional Materials. doi.org/10.1002/adfm.202314345.

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