Home Medizin Hyaluronsäure-Injektionen stimulieren die lang anhaltende Kollagenerneuerung bei gealterter Haut

Hyaluronsäure-Injektionen stimulieren die lang anhaltende Kollagenerneuerung bei gealterter Haut

von NFI Redaktion

Constant exposure of human skin to ultraviolet light leads to premature aging or photoaging. This exposure causes fragmentation of type I collagen bundles in the dermis, which is located beneath the top layer of skin and provides firmness and support to the skin, leading to wrinkles, fragility, and loss of firmness and elasticity.

„The best way to prevent damage to type I collagen caused by sunlight exposure is to consistently wear sunscreen, if possible daily and especially when outdoors.“

Frank Wang, MD, William B. Taylor Professor of Clinical Dermatology at UM Medical School

Experts found in a new study that injecting the most popular type of dermal fillers, crosslinked hyaluronic acid, into photoaged skin could reverse the skin changes associated with photoaging.

These fillers are typically injected into the skin to reduce lines and wrinkles. It is believed they cause clinical improvement by giving the skin more volume. However, researchers found that crosslinked hyaluronic acid also stimulates the production of new type I collagen in the dermis.

The filler works quickly and stimulates collagen production several weeks after injection. It is long-lasting and promotes the accumulation of more collagen over the course of a year.

These findings demonstrate how the filler improves the appearance of the skin in the short-term, a combination of space filling and collagen. As newly formed skin collagen lasts for many years, the results also shed light on how the filler can promote long-term clinical improvement, months or even a year after injection.

„A single injection of crosslinked hyaluronic acid dermal filler can lead to rapid and lasting improvement in the skin by stimulating collagen deposition. Additionally, repeated injections can add more collagen, ultimately reducing the need for re-treatment,“ said Wang.

Other authors include Thy Thy Do, Noah Smith, Jeffrey S. Orringer, Sewon Kang, John J. Voorhees, and Gary J. Fisher, all from the UM Department of Dermatology.


Michigan Medicine – University of Michigan

Journal Reference:

Wang, F., et al. (2024). Impact on cumulative and persistent clinical improvement by crosslinked hyaluronic acid: A biochemical/microscopic in-vivo study in humans. Experimental Dermatology. doi.org/10.1111/exd.14998.

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