Home Medizin Gezielte Augenspektroskopie wirft neues Licht auf die Netzhautgesundheit

Gezielte Augenspektroskopie wirft neues Licht auf die Netzhautgesundheit

von NFI Redaktion

Researchers recently published a study in the Journal of Biomedical Optics demonstrating the multimodal functionality of targeted ocular fluorescence spectroscopy in vitro and in vivo.

Studie: Gezielte Spektroskopie im Augenhintergrund. Bildnachweis: PeopleImages.com – Yuri A / Shutterstock.com

Hintergrund

The study discusses the significant structural and functional changes in the eyes, particularly at the optic fundus, caused by various eye diseases as well as neurological conditions such as Alzheimer’s and Parkinson’s.

Imaging methods other than targeted ocular diffuse reflection spectrophotometry (DRS) do not provide sufficient data on retinal changes caused by these diseases. Ocular DRS methods allow spectral analysis of specific parts of the optic fundus, including the papilla, peripheral retina, and fovea, between 500 and 800 nanometers (nm).

Diffuse reflection and fluorescence spectrophotometry also help elucidate the effects of factors such as the accumulation of lipofuscin, structural changes in the RNFL, blood absorption spectrum, and melanin spectral profile, all of which have an impact on the optical properties of retinal tissue.

Study Overview

The study initially identifies the key features of targeted ocular spectroscopy technology in vitro using a reference target and an eye model. It then moves on to perform in vivo imaging and DRS to assess blood oxygen saturation (StO2) in the optic nerve head and parafovea of eight healthy study participants.

The research involves capturing reflection spectra of blood vessels, the optic nerve, and retina in close proximity to and further away from the optic nerve head, all of which showed distinct reflection spectra. The average absorption spectra for both locations exhibited interindividual variability.

Study Findings

The study demonstrated the potential for identifying various fluorophores/chromophores present in the eye for diagnosing different retinal pathologies. The multimodal system developed for the study provided simultaneous and continuous imaging and targeted spectroscopy in the optic fundus, showing high sensitivity, spectral resolution, and short acquisition speed for detecting retinal biomarkers.

These findings indicate that targeted ocular spectroscopy has the potential to open new avenues for diagnosing and treating eye diseases over time, making it an important area for future research and development.

Journal Reference:

  • Lapointe, N., Akitegetse, C., Poirier, J., et al. (2023). Gezielte Spektroskopie im Augenhintergrund. Journal of Biomedical Optocs 28(12).doi:10.1117/1.JBO.28.12.126004

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