Home Medizin Frauen mit HIV erleben eine beschleunigte DNA-Alterung, wie eine Studie zeigt

Frauen mit HIV erleben eine beschleunigte DNA-Alterung, wie eine Studie zeigt

von NFI Redaktion

According to a study by Stephanie Shiau, an assistant professor in the Department of Biostatistics and Epidemiology at the Rutgers School of Public Health, women with HIV experience accelerated DNA aging, a phenomenon that can lead to impaired physical function.

Published in the Journal of Infectious Diseases, the study sheds light on the specific challenges faced by aging HIV-infected women and opens up opportunities for tailored interventions to improve health outcomes. Globally, over 50% of HIV-infected individuals are women, and in 2022, an estimated 46% of all new HIV infections were in women.

According to the results of the Women’s Interagency HIV Study, women with HIV are more likely to experience bone loss compared to women without the virus, putting them at a higher risk of fractures as they age.

„Understanding the molecular mechanisms behind accelerated aging in people with HIV is crucial for the development of targeted interventions and improving the quality of life of those living with the virus.“

– Stephanie Shiau, Assistant Professor, Department of Biostatistics and Epidemiology, Rutgers School of Public Health

Shiau mentioned that while accelerated aging has been reported in people with HIV, these studies have primarily been conducted in men and not in women.

The study focused on a sample of 195 women with HIV aged 40 to 60, comparing them to a cohort of women without the virus, and conducted various analyses to examine how aging markers measured in the blood are associated with bone mineral density and measurements of physical function such as muscle strength, walking speed, balance, and endurance.

The study’s findings showed that women with HIV exhibit faster aging compared to their chronological age.

In both groups, women who were unable to stand on one leg for 30 seconds showed increased aging, indicating potential associations between accelerated aging and specific aspects of physical function and underscoring the need for further research to confirm and understand these associations over time.

„The work shows that women with HIV undergo accelerated aging at the DNA level and that this aging process may potentially be linked to functional outcomes,“ said Shiau. „Future studies need to see if these results are observed longitudinally.“

The research not only provides insights into the challenges faced by women with HIV, but also lays a foundation for further investigating the long-term consequences for people living with the virus.

Co-authors of the study include researchers from collaborating institutions in New York, Illinois, and California.

Source:

Journal Reference:

Shiau, S., et al. (2024) Epigenetic Aging and Musculoskeletal Outcomes in a Cohort of Women Living with HIV. Journal of Infectious Diseases. doi.org/10.1093/infdis/jiae016.

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