Home Medizin Fortschrittliches Hydrogel fördert die Wundheilung im Gastrointestinaltrakt

Fortschrittliches Hydrogel fördert die Wundheilung im Gastrointestinaltrakt

von NFI Redaktion


Gastrointestinal (GI) surgeries, interventional screening procedures like colonoscopies, and naturally occurring complications like ulcers can lead to adverse events such as internal bleeding, intestinal wall perforations, and leakages. To address the limitations of current materials for gastrointestinal wound care, researchers at Brigham and Women’s Hospital, a founding member of the Mass General Brigham health system, have developed a sprayable, adhesive hydrogel product.

The research team has created a unique biomaterial to promote wound healing under various harsh conditions in the gastrointestinal tract that make healing these wounds particularly challenging, such as acidic pH, enzymes, bacteria, and muscle contractions. They have also designed the material to be easy to apply and compatible with current technology. Administration is done through a tiny catheter small enough to be inserted into any standard endoscope. Upon contact with tissue, the material immediately forms a protective adhesive seal.

In preclinical studies on large animal models, the research team found that the hydrogel, which the researchers commercially referred to as „Gastroshield,“ promoted rapid wound healing, provided longer tissue protection, and minimized the risk of delayed complications. Compared to six commercially available materials on the market for gastrointestinal wound healing, it showed superior durability lasting 3 to 7 days compared to 1 to 2 days, and exhibited the adhesive properties of the strongest materials on the market without cytotoxic properties.

Our tissue-reactive adhesive technology is designed to interact with the tissue to provide longer lesion protection over days,“ said Natalie Artzi, PhD, a biomedical engineer at Brigham and Women’s and co-founder of BioDevek, which holds patents on the materials and is advancing efforts to guide the next steps to bring Gastroshield from the lab to the clinic.

This approach allows us to prevent complications following polyp removal and treat other bleeding-prone wounds in traditionally hard-to-seal tissues throughout the gastrointestinal tract, paving the way for the future development of biomaterials for minimally invasive surgical procedures.“

Quelle:

Brigham and Women’s Hospital

Zeitschriftenreferenz:

Taboada, GM, et al. (2024). Sprühbares Hydrogel-Versiegelungsmittel zur Abschirmung von Magen-Darm-Wunden. Fortgeschrittene Werkstoffe. doi.org/10.1002/adma.202311798.

Related Posts

Adblock Detected

Please support us by disabling your AdBlocker extension from your browsers for our website.