Home Medizin Forscher entwickeln eine kostengünstige Methode zur räumlichen Charakterisierung und Kartierung von Gehirnepigenomen

Forscher entwickeln eine kostengünstige Methode zur räumlichen Charakterisierung und Kartierung von Gehirnepigenomen

von NFI Redaktion

According to the American Brain Foundation, approximately one out of every six people worldwide suffers from a brain disorder. While current research has provided some insights into cell communication in the brain, there are still many unknowns about how this vital organ functions. Imagine a comprehensive map that not only considers the biology of the brain but also the specific location where biology occurs. Researchers at the College of Engineering have developed a powerful and cost-effective method to achieve just that.

Led by Chang Lu, the Fred W. Bull Professor of Chemical Engineering, this groundbreaking research project aims to map and visualize brain biology on a genome scale in the most cost-effective way to improve healthy functioning. Collaborating with faculty members from two other departments within the College of Engineering, namely Xiaoting Jia and Daphne Yao, their goal is to understand and study the epigenomics of the brain in response to various activities or certain disorders such as seizures, epilepsy, addiction, or other mental illnesses.

The current method of brain mapping involves profiling individual cells one by one. While this approach provides high spatial resolution and valuable information about cell communication in the brain, it is expensive and time-consuming. Lu and his team have developed a more cost-effective approach to spatial methods: epigenomic tomography. By creating a detailed map of epigenomics or the profile of epigenetic changes on a genome scale across a large area and volume of the brain, they aim to understand how environmental factors affect gene behavior outside of DNA sequences.

Their method involves dividing the brain into small sections, creating separate profiles for each section using low-input technology, grouping features based on spatial variation patterns using clustering algorithms, and creating brain tomographies for both healthy and diseased brains. This innovative approach will provide valuable insights into the molecular processes underlying brain disorders and help in developing new treatment options.

By combining expertise from different disciplines, this research team hopes to make significant advancements in understanding brain disorders and developing new drugs. The interdisciplinary collaboration between ChemE, Electrical and Computer Engineering, and Computer Science demonstrates the importance of teamwork in solving complex problems. As Lu stated, “We hope that more researchers will join us to make advancements in brain disorders. It is important research for people suffering from depression and addiction, which is a significant percentage of our population.”

Through their collaboration, Lu, Jia, and Yao aim to shed light on the molecular processes in the brain and pave the way for effective treatments for various neurological conditions. This research not only showcases the power of interdisciplinary collaboration but also highlights the importance of technology in advancing our understanding of brain disorders.

Related Posts

Adblock Detected

Please support us by disabling your AdBlocker extension from your browsers for our website.