Home Medizin Fischöl in der Schwangerschaft steht im Zusammenhang mit Gewichtszunahme des Kindes und Stoffwechselrisiken

Fischöl in der Schwangerschaft steht im Zusammenhang mit Gewichtszunahme des Kindes und Stoffwechselrisiken

von NFI Redaktion

A study published in The American Journal of Clinical Nutrition claims that a fish oil supplement during pregnancy may increase the risk of weight gain and metabolic syndrome in offspring at the age of ten.










Study: Fish oil supplementation during pregnancy, anthropometry and metabolic health at ten years of age: A randomized clinical trial

Background

The prevalence of obesity and overweight has significantly increased in children and adolescents over the past decades. Environmental influences during pregnancy are known to play an important role in modulating the body composition of infants later in life. Among the various environmental exposures, the intake of long-chain polyunsaturated n-3 fatty acids (LCPUFAs) derived from fatty fish has gained considerable attention due to their known health benefits.

Several human observational studies and animal studies have shown that the intake of fatty fish or LCPUFAs during pregnancy is associated with a lower Body Mass Index (BMI) and healthier metabolic profiles in offspring.

The authors of this study previously conducted a randomized controlled trial on fish oil supplementation during the third trimester of pregnancy to determine its effects on the growth and body composition of offspring at six years of age. They observed an increase in BMI, fat, muscle, and bone mass in the offspring.

In this article, the researchers reported the results of their extended follow-up study, which included an assessment of the metabolic health of offspring at the age of ten.

About the randomized controlled trial

The study was conducted on a total of 736 pregnant women and their offspring who participated in the Copenhagen Prospective Studies on Asthma in Childhood mother-child cohort. The pregnant women were randomly assigned to the intervention group and control group in the 24th week of pregnancy.

In the intervention and control groups, participants received 2.4 grams of n-3 LCPUFAs daily or similar capsules of olive oil. The supplementation continued until one week after birth.

The parameters assessed in the study included anthropometric measurements, body composition, blood pressure, triglyceride and cholesterol concentrations, fasting glucose and C-peptide concentrations, and a metabolic syndrome score.

Key Observations

A total of 688 children with one or more anthropometric measurements were included in the analysis. Of these, 341 belonged to the intervention group and 347 to the control group.

The assessment of BMI, growth, and body composition of children at age ten revealed that children in the intervention group had a significantly higher BMI than children in the control group. They also had a higher risk of being overweight compared to children in the control group.

However, the differences observed in BMI and overweight risk between the intervention and control groups decreased after adjusting for strong growth-related risk factors in children, including maternal pre-pregnancy BMI, smoking during pregnancy, parity, and duration of exclusive breastfeeding.

Regarding body composition, the study found that children in the intervention group did not have significantly higher muscle mass, fat mass, or fat percentage than those in the control group.

Regarding the metabolic syndrome outcomes, the study found that supplementing with LCPUFAs during pregnancy did not affect blood sugar and lipid levels, waist circumference, and blood pressure in corresponding children at ten years of age. However, all estimates pointed to a less healthy metabolism in children of the intervention group.

The estimation of metabolic syndrome scores showed that children in the intervention group had higher average values than those in the control group.

The results of the mediation analysis showed that the observed outcomes in children of the intervention group were not mediated by their physical activity, eating habits, and puberty stage. Additionally, no significant difference in the effect of LCPUFA supplementation on anthropometric and metabolic measurements was observed between boys and girls at ten years of age.

Study Significance

The study concludes that children of mothers who received an LCPUFA supplement in the third trimester of pregnancy have a significantly higher BMI and a substantially higher risk of obesity at the age of ten. They also tend to have an increased fat percentage and higher values for metabolic syndrome.

Overall, the study results suggest that fish oil or LCPUFA supplementation during pregnancy may have negative effects on offspring health.

Related Posts

Adblock Detected

Please support us by disabling your AdBlocker extension from your browsers for our website.