Home Medizin Es wurde festgestellt, dass die mit der Bewegung verbundene Gehirnregion bei Kindern mit einer Sprachentwicklungsstörung abnormal ist

Es wurde festgestellt, dass die mit der Bewegung verbundene Gehirnregion bei Kindern mit einer Sprachentwicklungsstörung abnormal ist

von NFI Redaktion

Neuroscientists at Georgetown University Medical Center have conducted a thorough analysis of numerous studies, concluding that a part of the brain traditionally associated with movement is abnormal in children with speech development disorders. This discovery has the potential to improve both the diagnosis and treatment of speech difficulties.

The researchers investigated brain anomalies in language developmental disorders, a condition that affects the development of various aspects of language and is as common as attention deficit/hyperactivity disorder (ADHD) and dyslexia, and more common than autism. They found that anomalies specifically occurred in the anterior neostriatum within the basal ganglia, a deep brain structure. They describe their findings in Nature Human Behavior on March 15.

To better understand why speech impairments occur, the researchers analyzed the results of 22 articles examining brain structures in people with this disorder, then used a new calculation method to identify common patterns of anomalies across the studies. They found that the anterior neostriatum was abnormal in 100% of studies where the structure was examined, while fewer anomalies occurred in all other parts of the brain.

„By identifying the neural underpinnings of developmental language difficulties, we hope to raise awareness of a severe, yet often unrecognized disorder. However, we caution that further research is needed to understand exactly how the anterior neostriatum could lead to speech difficulties.“

Michael T. Ullman, PhD, lead author of the study, Professor of Neuroscience and Director of the Brain and Language Laboratory at Georgetown University Medical Center

Ullman suggests that the results emphasize the potential benefits of medications known to improve movement impairments due to basal ganglia dysfunction, such as those acting on dopamine receptors. Interventions promoting compensation through intact brain structures may also be beneficial. Furthermore, basal ganglia anomalies could potentially serve as early biomarkers for an increased likelihood of speech development problems. Such early warning signs could trigger further diagnostic measures and potentially lead to early intervention.

„Continued research efforts to better understand the neurobiology of speech development disorders, particularly the role of the basal ganglia, could help the many children affected by these issues,“ concludes Ullman.

Other authors at Georgetown include Mariel Pullman, Jarrett Lovelett, Xiong Jiang, and Peter Turkeltaub. Gillian Clark was at Deakin University in Melbourne, Australia. Elizabeth Pierpont is at the University of Minnesota Medical Center in Minneapolis.

This work was supported by NIH grants R01 HD049347 and R21 HD 087088; NSF grants BCS 1439290 and BCS 1940980; and funding from the Mabel H. Flory Trust.

The authors report no personal financial interests related to the study.


Georgetown University Medical Center

Journal Reference:

Ullman, MT, et al. (2024). The Neuroanatomy of Developmental Language Disorder: a Systematic Review and Meta-analysis. Nature Human Behavior. doi.org/10.1038/s41562-024-01843-6.

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