Home Medizin Die Prävalenz antimikrobieller Resistenzen hängt vom Alter und Geschlecht des Patienten ab

Die Prävalenz antimikrobieller Resistenzen hängt vom Alter und Geschlecht des Patienten ab

von NFI Redaktion

According to a new study published in PLOS Medicine, a person’s age and gender are correlated with the likelihood of suffering from a bloodstream infection caused by antibiotic-resistant bacteria.

Antibiotic resistance (AMR), including infections that cannot be treated with antibiotics, is a major global threat to public health. Little is known about how resistance prevalence varies depending on the patient’s age and gender, although both factors are related to differences in antibiotic usage, changes in immune function, and exposure to high-risk environments.

In the new study led by researchers from the London School of Hygiene & Tropical Medicine (LSHTM), data collected between 2015 and 2019 as part of routine monitoring of blood circulation infections in 944,520 people across 29 European countries was analyzed. The team examined which bacterial species were isolated and sent to the surveillance service and which antibiotics were used to treat the infections.

Different patterns in resistance prevalence by age were observed throughout Europe, but these patterns varied depending on the type of bacteria. Most, but not all, bacteria showed resistance peaks in the youngest and oldest age groups.

The occurrence of Methicillin-resistant Staphylococcus aureus (MRSA) increased with age, and the presence of Aminopenicillin resistance in Escherichia coli decreased with age. Some antimicrobial resistance profiles peaked in middle age; Pseudomonas aeruginosa showed a peak in resistance to multiple antibiotics around age 30, and for women, the occurrence of bloodstream infections due to E. coli peaked between 15 and 40 years of age.

There were other significant differences between genders; generally, men had a higher risk of antimicrobial resistance compared to women.

Our findings highlight important gaps in our knowledge about the spread and selection of antimicrobial resistances (AMR) and may help us understand why the epidemiology is hard to explain based on known patterns of antibiotic exposure and health contacts.


They also suggest that interventions aimed at reducing the burden of antimicrobial resistance should consider important differences in resistance prevalence by age and gender.


To address this growing public health threat, we now need data from a wider range of sources to determine the contribution of cultural and natural history differences to the development of these patterns worldwide, and the role they play in the observed rising rates of antimicrobial resistance.“


Dr. Gwen Knight, Associate Professor and Co-Director of the AMR Center at LSHTM

Source:

London School of Hygiene & Tropical Medicine (LSHTM)

Journal Reference:

Waterlow, NR, et al. (2024). Prevalence of antimicrobial resistances in bloodstream infections in 29 European countries by age and gender: An observational study. PLOS Medicine. doi.org/10.1371/journal.pmed.1004301.

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