Home Medizin Die Kryoablation löst bei Patienten mit paroxysmalem Vorhofflimmern systemische Stoffwechselveränderungen aus

Die Kryoablation löst bei Patienten mit paroxysmalem Vorhofflimmern systemische Stoffwechselveränderungen aus

von NFI Redaktion


An announcement of a new article publication for the Cardiovascular Innovations and Applications journal. Cryoablation (CRYO) is a novel catheter ablation technique for atrial fibrillation (AF). However, there remains uncertainty regarding the role of metabolic changes associated with CRYO. The aim of this study was to investigate if CRYO affects the metabolic signature – a possibility that has not been explored before.

Paired serum samples from patients with atrial fibrillation (n = 10) were collected before and 24 hours after CRYO. Untargeted metabolomic analysis was conducted using LC-MS. Univariate and multivariate analyses were applied to identify different metabolites between samples. Pathway enrichment and Pearson correlation analyses were performed to uncover disrupted metabolic pathways and potential interactions.

The concentrations of 19 metabolites showed significant changes between baseline and 24 hours after CRYO. Pathway analysis revealed that the disrupted metabolites were enriched in unsaturated fatty acid biosynthesis, retrograde endocannabinoid signaling, and neuroactive ligand-receptor interactions. Pearson correlation analysis showed strong correlations between different metabolites, biochemical markers, and clinical indicators.

CRYO induces systemic changes in the serum metabolome of patients with paroxysmal atrial fibrillation and offers potential metabolic benefits. These findings could lead to a better understanding of the pathophysiology and metabolic mechanisms in catheter ablation.

Source:

Journal reference:

Xie, M., et al. (2024) Incremental Metabolic Benefits of Cryoablation in Paroxysmal Atrial Fibrillation: Insights from Metabolomic Profiling. Cardiovascular Innovations and Applications. doi.org/10.15212/CVIA.2023.0079.

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