Home Medizin Die Kombination von gerinnungshemmenden und blutverdünnenden Mitteln bringt für Menschen mit ischämischen Schlaganfällen keinen Vorteil

Die Kombination von gerinnungshemmenden und blutverdünnenden Mitteln bringt für Menschen mit ischämischen Schlaganfällen keinen Vorteil

von NFI Redaktion

Recent preliminary findings presented at the 2024 International Stroke Conference of the American Stroke Association revealed that administering blood thinners in addition to anticoagulants to people with ischemic strokes did not improve their outcomes 90 days later. The study, called MOST (Multi-Arm Optimization of Stroke Thrombolysis), involved 57 centers in the U.S. and was halted after analyzing the results of the first 500 patients out of the planned 1,200 participants. The objective was to improve functional outcomes after 90 days but was ultimately found to be highly unlikely.

„When we started the study, we believed that the medications would improve the results and were therefore surprised by the negative findings. However, we designed the study to efficiently answer the question about two blood thinners in one study, and we have definitely accomplished that and are pleased to be able to answer that question.“

– Opeolu M. Adeoye, MD, MS, lead author of the study and BJC HealthCare Distinguished Professor of Emergency Medicine and Chair of the Department of Emergency Medicine at the Washington University School of Medicine in St. Louis, Missouri.

Out of the 514 patients enrolled before the study was discontinued in July 2023, none of the blood thinners used improved the outcomes for stroke survivors. Additionally, the risk of brain bleeding was not significantly increased by the two blood thinners. The study was conducted from October 2019 to July 2023 at 57 hospitals in the United States, and all participants had an ischemic stroke rated 6 or higher on the National Institutes of Health Severity Scale and were considered to have a moderate stroke. The participants, who were on average 68 years old, were treated with the standard approach of thrombolysis within three hours of the onset of stroke symptoms.

Overall, the study did not find a benefit to administering blood thinners in addition to anticoagulant medications to people who suffer from ischemic strokes. The findings of the study were presented at the conference and were funded by the National Institute of Neurological Disorders and Stroke, a division of the National Institutes of Health.

Source:

American Heart Association

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