Research conducted on the effects of the diabetes medication dulaglutide (Trulicity) has revealed that it can significantly lower the risk of substantial weight gain in women after they quit smoking. This was published in the Open Access Journal BMJ Nutrition, Prevention, and Health.
The analysis showed that the likelihood of significant weight gain in women after quitting smoking is five times higher than in men.
It has been suggested that women may have a higher rate of smoking relapse compared to men due to concerns about significant weight gain after quitting, even though there is no substantial evidence for this, according to the researchers.
Previous clinical study results revealed that dulaglutide significantly reduced weight gain in those who quit smoking compared to a placebo. However, the researchers were unsure if this weight loss was gender-specific.
Therefore, the study data was re-analyzed to determine gender-specific differences in weight loss or gain in the 12 weeks after an attempt to quit smoking.
The study included 255 adults, with 155 being women. The average age was between 42 and 44 years, and the average number of cigarettes smoked daily over a period of 19-22 years was 20.
Baur, F., et al. (2023). Gender-specific differences in weight gain during attempted and successful smoking cessation under dulaglutide treatment: a pre-specified secondary analysis of a randomized study. BMJ Nutrition, Prevention, and Health. doi.org/10.1136/bmjnph-2023-000781.