Home Medizin Der Einsatz von Antibiotika bei der Mutter während der Geburt ist mit einem höheren Risiko für Autoimmunerkrankungen bei Kindern verbunden

Der Einsatz von Antibiotika bei der Mutter während der Geburt ist mit einem höheren Risiko für Autoimmunerkrankungen bei Kindern verbunden

von NFI Redaktion

Children born to mothers who received antibiotic treatment during childbirth are more likely to develop autoimmune diseases compared to their peers. This is the result of a recent registry study conducted at the University of Oulu, Finland, involving nearly 46,000 children. The most common autoimmune diseases in children include type 1 diabetes, celiac disease, and rheumatic conditions. However, the study found that administering antibiotics during childbirth showed no association with allergic diseases or asthma in the child.

An antibiotic treatment administered to mothers during delivery effectively prevents rare severe infections caused by group B streptococci in newborns, reducing associated mortality. In Finland, mothers are given antibiotics during childbirth if group B streptococci are detected in the birth canal before delivery, and nearly one in four women giving birth vaginally receive antibiotic treatment.

The research results play a crucial role in assessing the potential drawbacks of perinatal antibiotic use and investigating the underlying mechanisms of immune-related diseases. Previous findings suggest that antibiotics given to mothers during childbirth may influence the child’s gut microbiota development. The study supports the notion that normal gut microbiota could have long-term effects on a child’s health.

This is an observational study that does not establish a direct cause-and-effect relationship between the antibiotics administered to mothers during childbirth and the child’s later health. The result is a statistical association that may also be influenced by other factors.“


Sofia Ainonen, lead author of the article and doctoral candidate at the University of Oulu

According to Professor Terhi Ruuska, who led the study, the results support the development of precise prevention methods for group B streptococcal infections. One possible method could be a vaccine administered to mothers that does not affect the child’s normal microbiota.

The study followed children born vaginally between 2007 and 2018 at Oulu University Hospital (OYS) and Oulaskangas Hospital in North Ostrobothnia, Finland. The study utilized national registers from the National Institute for Health and Welfare, the Finnish Social Insurance Institution (Kela), and Statistics Finland, as well as high-quality electronic patient records from hospitals in the OYS region providing comprehensive information on the mother’s antibiotic exposure.

The pre-approved version of the study was published in the American Journal of Obstetrics and Gynecology on February 16.

Source:

Journal Reference:

Ainonen, S., et al. (2024) Risks of childhood immune-related diseases following intrapartum antibiotic exposure. American Journal of Obstetrics and Gynecology. doi.org/10.1016/j.ajog.2024.02.020.

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