Home Medizin Das metabolische Syndrom erhöht das Sterberisiko bei Frauen mit Hochrisiko-HPV

Das metabolische Syndrom erhöht das Sterberisiko bei Frauen mit Hochrisiko-HPV

von NFI Redaktion

Researchers at the York University Faculty of Health in the United States analyzed extensive data spanning more than a decade and found that women with both metabolic syndrome and high-risk strains of human papillomavirus (HPV) have a 2.6 times higher risk of mortality than women without either condition, suggesting that comorbid chronic diseases need to be examined in HPV-related cancer cases.

„While it has been known for some time that metabolic disorders can contribute to persistent HPV infection, this study expands previous work by investigating the links to mortality risk,“ says Catriona Buick, Assistant Professor at the School of Nursing, also an oncology nurse and clinical scientist at Sunnybrook Health Sciences Center.

Buick, an expert in HPV, women’s health, and cancer treatment, collaborated with School of Kinesiology and Health Science doctoral student Parmis Mirzadeh, whose research focuses on obesity and metabolic diseases, to examine the connection more closely.

Data for the study, published yesterday in PLUS ONE, was derived from the United States National Health and Nutrition Examination Survey with a final sample of 5,101 individuals (3,274 women). The researchers found that more than a quarter of women with metabolic syndrome had high-risk HPV.

Their study did not indicate increased mortality solely based on HPV status, which the researchers attribute to the fact that the data only allowed for a snapshot of whether a woman had HPV or not, and did not provide information on its persistence.

HPV is the most common sexually transmitted infection and is often referred to as the most prevalent sexually transmitted flu. In most cases, the body clears HPV fairly quickly, but persistent cases of high-risk HPV can develop into precancerous changes in the cervix and in some cases progress to cervical cancer over many years.“

Catriona Buick, Assistant Professor and Oncology Nurse, Clinical Scientist, Sunnybrook Health Sciences Center

While most of the 200 known strains pose no serious problem, a handful are responsible for almost all cases of cervical cancer, accounting for 4.5% of all cancer cases worldwide.

Metabolic syndrome refers to a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes. This includes excess fat around the waist, high fasting blood sugar levels, and high blood pressure. Although not directly examined in this study, individuals with metabolic syndrome are about 65% more likely to develop cardiovascular disease and have a 25% higher likelihood of dying from „any“ cause. It is unclear how metabolic syndrome could impact HPV.

One in five Canadian adults suffers from metabolic syndrome, and these numbers are rising. Both Buick and Mirzadeh emphasize the importance of a healthy lifestyle, routine cancer screenings, and HPV vaccination.

Jurisdictions in Canada and around the world are moving away from Pap smears and towards HPV testing, which according to Buick, can alert doctors earlier to potential issues and do not need to be performed as frequently. Although HPV vaccinations are very helpful, they only protect against a handful of the most common of the 40 known carcinogenic HPV strains, says Buick.


Journal Reference:

Mirzadeh, P., et al. (2024). Association Between Human Papillomaviruses, Metabolic Syndrome, and Overall Mortality; Analysis of US NHANES 2003–2004 to 2015–2016. PLUS ONE. doi.org/10.1371/journal.pone.0299479.

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