A new research paper has been published in the Altern (listed in MEDLINE/PubMed as „Aging (Albany NY)“ and „Aging-US“ by Web of Science) Volume 15, Issue 23, titled „Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in vascular dysfunction.“
Angelica gigas NAKAI (AG) is a popular traditional medicinal herb commonly used for the treatment of dyslipidemia due to its antioxidant effects. Vascular diseases are closely associated with metabolic syndrome caused by obesity, and AG extract (AGE) has shown positive effects on obesity-induced vascular dysfunction. However, the effectiveness of AGE against obesity and the underlying mechanisms have not been extensively studied. In this new study, researchers Geum-Hwa Lee, Hwa-Young Lee, Young-Je Lim, Ji-Hyun Kim, Su-Jin Jung, Eun-Soo Jung, Soo-Wan Chae, Juwon Lee, Junghyun Lim, Mohammad Mamun Ur Rashid, Kyung Hyun Min, and Han-Jung Chae from Jeonbuk National University and Jeonbuk National University Hospital supplemented 40 rats on a high-fat diet (HFD) with 100–300 mg/kg/day AGE to determine its effectiveness in regulating vascular dysfunctions.
„[…] The main aim of this study is to explore the inhibitory effect of AGE on dyslipidemia-associated vascular dysfunctions, focusing on its potential mechanisms of action.“
Vascular relaxation responses to acetylcholine were impaired in HFD rats, while administration of AGE restored the diminished relaxation pattern. In HFD rats, endothelial dysfunctions were observed, including enlarged plaque area, accumulated reactive oxygen species, and decreased phosphorylation of nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) Ser1177, whereas AGE reversed the endothelial dysfunction and associated biochemical signal transduction. Furthermore, AGE regulated endoplasmic reticulum (ER) stress and IRE1α sulfonation, as well as subsequent Sirt1 RNA decay by controlling regulated IRE1α-dependent decay (RIDD) signaling, ultimately promoting NO bioavailability through the SIRT1-eNOS axis in aorta and endothelial cells.
Regardless, AGE increased AMPK phosphorylation and additionally stimulated SIRT1 and eNOS deacetylation and associated NO bioavailability. Decursin, a key component of AGE, exhibited a similar effect in alleviating endothelial dysfunctions. These data suggest that AGE regulates dyslipidemia-associated vascular dysfunctions by controlling ROS-associated ER stress responses, particularly IRE1α-RIDD/Sirt1 decay, and AMPK-SIRT1 axis.
„Ultimately, this study provides clear evidence that AGE is a promising candidate for functional foods/herbal medicine based on natural products for the prevention or regulation of hyperlipidemic cardiovascular complications.“
Lee, G.-H., et al. (2023). Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in vascular dysfunction. Altern. doi.org/10.18632/aging.205343.