Home Medizin 13 neue Biomarker könnten dazu beitragen, das Risiko von Herzerkrankungen bei Menschen mit Typ-2-Diabetes besser vorherzusagen

13 neue Biomarker könnten dazu beitragen, das Risiko von Herzerkrankungen bei Menschen mit Typ-2-Diabetes besser vorherzusagen

von NFI Redaktion

An international academic consortium has identified 13 biomarkers that significantly improve the ability to accurately predict the risk of cardiovascular disease in people with type 2 diabetes. The analysis was led by experts from 23 individuals in 11 countries, with leadership from Johns Hopkins University in the United States, the Chinese University of Hong Kong in Hong Kong, and Lund University in Sweden.

Although the probability of cardiovascular disease in people with type 2 diabetes is twice as high as in people without diabetes, it is a challenge for doctors to predict who in this population is most at risk. Traditional risk assessments reflecting the level of risk based on certain risk factors are outdated and do not work well in different population groups.

„More than 500 million people worldwide live with diabetes. Given these high numbers, it is important to find readily available ways to accurately classify patients so those at higher risk of cardiovascular disease can receive the preventive care they need.“ - Maria F. Gomez, Ph.D., Co-lead author of the analysis, Research Group Leader at the University of Lund’s Diabetes Center and Professor of Physiology at the University of Lund

In this context, the research team reviewed and analyzed medical studies published from 1990 onwards that examined the differences between people with type 2 diabetes who had cardiovascular disease and those who did not have it.

„Our goal was to identify promising markers that could improve the prediction of cardiovascular risk in people with type 2 diabetes,“ says Nestoras Mathioudakis, MD, MHS, Co-Senior-Author of the analysis, Co-Medical Director of the Johns Hopkins Medicine Diabetes Prevention & Education Program, and Associate Professor of Medicine at the Johns Hopkins University School of Medicine. „We wanted to look beyond traditional prognostic factors such as high blood pressure and smoking.“

The team extracted data on 321 biomarkers from the review and analysis of published medical literature and found that 13 were significantly associated with cardiovascular risk in people with type 2 diabetes. The standout biomarker was the N-terminal pro-B-type natriuretic peptide (NT-proBNP), currently used to monitor heart failure status in patients. The team found in several studies that higher NT-proBNP levels in the body were correlated with a higher risk of cardiovascular disease. A study reviewed by the team with 16,000 patients found a 64% increase in hazard rate for each increase in standard deviation of NT-proBNP.

„The 13 biomarkers, especially NT-proBNP, require further testing to assess their potential,“ says Ronald Ma, MBBChir., FRCP, FHKCP, FHKAM, Co-Senior-Author of the analysis and SH Ho Professor of Diabetes at the Chinese University of Hong Kong. „If future studies confirm their value for predicting cardiovascular risk in patients with type 2 diabetes, we may be able to change care standards.“

The study was conducted as part of the Precision Medicine in Diabetes Initiative, an international partnership between the American Diabetes Association and the European Association for the Study of Diabetes.

The analysis was published on January 22 in Communications Medicine.


Journal reference:

Ahmad, A., et al. (2024). Precise prediction of cardiovascular disease in type 2 diabetes: a systematic review and meta-analysis. Communications Medicine. doi.org/10.1038/s43856-023-00429-z.

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